Design Rules for Selective Binding of Nuclear Localization Signals to Minor Site of Importin α

@inproceedings{Pang2014DesignRF,
  title={Design Rules for Selective Binding of Nuclear Localization Signals to Minor Site of Importin α},
  author={Xiaodong Pang and Huan-Xiang Zhou},
  booktitle={PloS one},
  year={2014}
}
Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The selectivity for the minor site is dissected by building… CONTINUE READING