Design Principles of the Yeast G1/S Switch

@inproceedings{Yang2013DesignPO,
  title={Design Principles of the Yeast G1/S Switch},
  author={Xiaojing Yang and K. S. Y. Lau and Volkan Sevim and Chao Tang},
  booktitle={PLoS biology},
  year={2013}
}
A hallmark of the G1/S transition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichiometric inhibitor Sic1. Deleting SIC1 or altering Sic1 degradation dynamics increases genomic instability. Certain key facts about the parts of the G1/S circuitry are established: phosphorylation of Sic1 on multiple sites is necessary for its destruction, and both the upstream kinase Cln1/2-Cdk1 and the downstream kinase Clb5/6-Cdk1 can phosphorylate Sic1 in vitro with… CONTINUE READING

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