Design Expert Supported Mathematical Optimization and Predictability Study of Buccoadhesive Pharmaceutical Wafers of Loratadine

@inproceedings{Chakraborty2013DesignES,
  title={Design Expert Supported Mathematical Optimization and Predictability Study of Buccoadhesive Pharmaceutical Wafers of Loratadine},
  author={Prithviraj Chakraborty and Surajit Dey and Versha Parcha and Shiv Sankar Bhattacharya and Amitava Ghosh},
  booktitle={BioMed research international},
  year={2013}
}
OBJECTIVE The objective of this work encompasses the application of the response surface approach in the development of buccoadhesive pharmaceutical wafers of Loratadine (LOR). METHODS Experiments were performed according to a 3(2) factorial design to evaluate the effects of buccoadhesive polymer, sodium alginate (A), and lactose monohydrate as ingredient, of hydrophilic matrix former (B) on the bioadhesive force, disintegration time, percent (%) swelling index, and time taken for 70% drug… CONTINUE READING

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