Design Considerations of Iron-Based Nanoclusters for Noninvasive Tracking of Mesenchymal Stem Cell Homing

@inproceedings{Huang2014DesignCO,
  title={Design Considerations of Iron-Based Nanoclusters for Noninvasive Tracking of Mesenchymal Stem Cell Homing},
  author={Xinglu Huang and Fan Zhang and Yu Wang and Xiaolian Sun and Ki Young Choi and Dingbin Liu and Jin-sil Choi and Tae-Hyun Shin and Jinwoo Cheon and Gang Niu and Xiaoyuan Chen},
  booktitle={ACS nano},
  year={2014}
}
Stem-cell-based therapies have attracted considerable interest in regenerative medicine and oncological research. However, a major limitation of systemic delivery of stem cells is the low homing efficiency to the target site. Here, we report a serendipitous finding that various iron-based magnetic nanoparticles (MNPs) actively augment chemokine receptor CXCR4 expression of bone-marrow-derived mesenchymal stem cells (MSCs). On the basis of this observation, we designed an iron-based nanocluster… CONTINUE READING
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