• Published 2002

Design , Synthesis , and Biological Evaluation of a Dual Tumor-specific Motive Containing Integrin-targeted Plasmin-cleavable Doxorubicin Prodrug 1

@inproceedings{Groot2002DesignS,
  title={Design , Synthesis , and Biological Evaluation of a Dual Tumor-specific Motive Containing Integrin-targeted Plasmin-cleavable Doxorubicin Prodrug 1},
  author={Franciscus Marinus Hendrikus De Groot and H. J. G. Broxterman and H. P. H. M. Adams and Alexandra van Vliet and Godefridus Ignatius Tesser and Yvonne W. Elderkamp and Astrid J. Schraa and Robbert Jan Kok and Grietje Molema and Herbert Michael Pinedo and Hans W. Scheeren},
  year={2002}
}
The design, synthesis, and initial biological evaluation of a doxorubicin prodrug that contains a dual tumor specific moiety, which allows enhanced tumor recognition potential, is reported. Both a tumorspecific recognition site and a tumor selective enzymatic activation sequence are incorporated in the prodrug. The first tumor-specific sequence is the bicyclic CDCRGDCFC (RGD-4C) peptide that selectively binds v 3 and v 5 integrins. These integrins are highly overexpressed on invading tumor… CONTINUE READING

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