Design, synthesis of new β-carboline derivatives and their selective anti-HIV-2 activity.

@article{Ashok2015DesignSO,
  title={Design, synthesis of new β-carboline derivatives and their selective anti-HIV-2 activity.},
  author={Penta Ashok and Subhash Chander and Jan Balzarini and C Pannecouque and Sankaranarayanan Murugesan},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 6},
  pages={1232-5}
}
In the present study, a new series of β-carboline derivatives were synthesized and evaluated for inhibition activity against both HIV-1 and HIV-2 strains. Among these reported analogues, surprisingly (1-phenyl-9H-pyrido[3,4-b]indol-3-yl)(4-p-tolylpiperazin-1-yl)methanone (7b), (4-(2-methoxyphenyl)piperazin-1-yl)(1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methanone (7f), (4-(4-fluorophenyl)piperazin-1-yl)(1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methanone (7k), (4-(2-fluorophenyl)piperazin-1-yl)(1-phenyl-9H… CONTINUE READING