Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles.

@article{Ziedan2010DesignSA,
  title={Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles.},
  author={Noha I Ziedan and Fabio Stefanelli and Stefano Fogli and Andrew D Westwell},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 10},
  pages={4523-30}
}
A series of new indole-based 3,5-disubstituted 1,2,4-oxadiazoles has been designed and synthesised as potential pro-apoptotic antitumour agents, via the base-catalysed condensation reaction between substituted amidoximes and indole esters. Evaluation of antiproliferative activity against the human cancer cell lines COLO 320 (colorectal) and MIA PACA-2 (pancreatic) revealed IC(50) values in the low micromolar range. Selected compounds were able to trigger apoptosis in sensitive cell lines, for… CONTINUE READING