Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents.
@article{Guo2015DesignSA, title={Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents.}, author={Zhi-hua Guo and Yong Yin and Cong Wang and Peng-Fei Wang and Xingchuan Zhang and Zhong-Chang Wang and Hai‐Liang Zhu}, journal={Bioorganic \& medicinal chemistry}, year={2015}, volume={23 18}, pages={ 6148-56 } }
10 Citations
Metronidazole containing pyrazole derivatives potently inhibit tyrosyl‐tRNA synthetase: design, synthesis, and biological evaluation
- Biology, ChemistryChemical biology & drug design
- 2016
Four compounds have been synthesized and identified as TyrRS inhibitors with low cytotoxicity and significant antibacterial activity, especially against Gram‐negative organisms, and 4f is the most potent agent which inhibited the growth of Pseudomonas aeruginosa.
Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria
- Chemistry, Biology
- 2021
Results identify 7e and 7f as promising mitochondria-modulating and anticancer agents with increased cellular availability and the most lipophilic conjugates were found to specifically interact with ROS probe 2′,7′-dichlorofluorescin diacetate, forming mixed aggregates with the probe and inhibiting its fluorescence upon oxidation.
Novel derivatives of salicylanilide: Synthesis, characterization, PPO inhibitory activity and cytotoxicity
- Chemistry
- 2021
Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective.
- Biology, ChemistryEuropean journal of medicinal chemistry
- 2020
Tyrosyl-tRNA synthetase inhibitors: a patent review
- Chemistry, BiologyExpert opinion on therapeutic patents
- 2017
There is an urgent need to develop novel TyrRS inhibitors with higher activity and selectivity, based on the published SAR results, selective tyrosyl-tRNA synthetase inhibitors could be designed and developed as the next generation of antibacterial agents.
1,3,4-Oxadiazole as a Potential Anti-Cancer Scaffold: A Review
- Biology, ChemistryBiointerface Research in Applied Chemistry
- 2021
The present review gives an overview of the anti-cancer potential of 1,3,4-oxadiazoles derivatives in cancer drug discovery and development from the last ten years.
2,4‐Disubstituted 5‐Nitroimidazoles Potent against Clostridium difficile
- Biology, ChemistryChemMedChem
- 2019
The synthesis of new 2,4‐disubstituted 5‐nitroimidazole compounds that show potent antibacterial activity against C. difficile are reported.
Salicylic acid derivatives and phenylspirodrimanes from the sponge-associated fungus Hansfordia sinuosae
- ChemistryJournal of Asian natural products research
- 2018
Abstract Three new salicylic acid derivatives (1–3) and a known one, 6-(3′-hydroxypropyl)-2-hydroxybenzoic acid (4), together with seven known phenylspirodrimanes (5–11), were isolated from the…
ВЛИЯНИЕ МЕТРОНИДАЗОЛА НА БИОЛОГИЧЕСКОЕ ДЕЙСТВИЕ ДОКСОРУБИЦИНА
- Medicine, Chemistry
- 2017
The data obtained indicate that Metronidazole used in oncologic practice for the treatment and prevention of infectious complications, and as a radiosensitizer, can enhance the antitumor effect of Doxorubicin, but this effect is accompanied by a significant increase of the cytostatic toxicity.
References
SHOWING 1-10 OF 53 REFERENCES
Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents.
- Biology, ChemistryBioorganic & medicinal chemistry
- 2014
Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 2014
Dihydropyrazoles containing morpholine: design, synthesis and bioassay testing as potent antimicrobial agents
- Chemistry, Biology
- 2015
A series of dihydropyrazole derivatives containing morpholine was designed and synthesized as antimicrobial agents and exhibited the potential to be new a antibacterial drug with strong broad-spectrum antimicrobial activity and enzyme inhibitory activity.
Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
- Chemistry, BiologyBioorganic & medicinal chemistry letters
- 2014
Exploration of structure-based on imidazole core as antibacterial agents.
- Biology, ChemistryCurrent topics in medicinal chemistry
- 2013
The emergence of resistance to antibiotics is discussed and the main developments of imidazole derivatives in the past ten years are summarized to hope that increasing knowledge of the structure-activity relationship (SAR) will be beneficial to the rational design of new generation of small molecule antibacterial drugs.
Synthesis and antibacterial evaluation of novel Schiff's base derivatives of nitroimidazole nuclei as potent E. coli FabH inhibitors
- Chemistry, Biology
- 2014
Series of novel Schiff's base derivatives synthesized by combining 2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 4-formylbenzoate 5 with aromatic/heterocyclic amine with effective antibacterial and potential inhibitory activity against E. coli FabH.
Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors.
- Chemistry, BiologyBioorganic & medicinal chemistry
- 2009
Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity.
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 2014
Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis.
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 2013
Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones.
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 2011