Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.


A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved insulin resistance through… (More)
DOI: 10.1016/j.bmcl.2009.04.050


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