Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment of Alzheimer’s disease

@article{Spilovska2015DesignSA,
  title={Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment of Alzheimer’s disease},
  author={K. Spilovska and J. Kor{\'a}be{\vc}n{\'y} and A. Horova and K. Musilek and E. Nepovimova and L. Drtinov{\'a} and Z. Gazova and K. Siposova and R. Dolezal and D. Jun and K. Ku{\vc}a},
  journal={Medicinal Chemistry Research},
  year={2015},
  volume={24},
  pages={2645-2655}
}
Abstract A series of cholinesterase inhibitors acting as dual binding site heterodimers for the management of Alzheimer’s disease were developed. The series of 7-methoxytacrine (7-MEOTA)-amantadine ureas (11–17) was designed, prepared evaluated in vitro towards human acetyl/butyryl cholinesterase (hAChE, hBChE) and compared with the series of 7-MEOTA-amantadine thioureas (4–10). The heterodimers have different length of linkers combining 7-MEOTA and amantadine moieties. In comparison with 7… Expand

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