Design, synthesis and in vitro evaluation of d-glucose-based cationic glycolipids for gene delivery.

@article{He2016DesignSA,
  title={Design, synthesis and in vitro evaluation of d-glucose-based cationic glycolipids for gene delivery.},
  author={Chengxi He and Shang Wang and Meiyan Liu and Chunyan Zhao and Shuanglin Xiang and Youlin Zeng},
  journal={Organic & biomolecular chemistry},
  year={2016},
  volume={14 5},
  pages={1611-22}
}
A cationic lipid consists of a hydrophilic headgroup, backbone and hydrophobic tails which have an immense influence on the transfection efficiency of the lipid. In this paper, two novel series of cationic cyclic glycolipids with a quaternary ammonium headgroup and different-length hydrophobic tails (dodecyl, tetradecyl, hexadecyl) have been designed and synthesized for gene delivery. One contains lipids 1-3 with two hydrophobic alkyl chains linked to the glucose ring directly via an ether link… CONTINUE READING