Design, synthesis and in vitro and in vivo antitumor activities of novel beta-carboline derivatives.

Abstract

To further our SAR study on the chemistry and antitumor activity/neurotoxicity of beta-carboline alkaloids, several series of beta-carboline derivatives with various substituents were designed and synthesized from the starting material l-tryptophan on the basis of harmine chemical structure. Cytotoxic activities of these compounds were investigated in vitro… (More)

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