Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.

@article{Francuz2017DesignSA,
  title={Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.},
  author={Jovana Francuz and Ivana Kova{\vc}evi{\'c} and Mirjana Popsavin and Goran Benedekovic and Bojana Sre{\'c}o Zelenovi{\'c} and Vesna Koji{\'c} and Dimitar S. Jakimov and Lidija D. Aleksi{\'c} and Gordana Bogdanovic and Tatjana Srdi{\'c}-Raji{\'c} and Eva S. Lon{\vc}ar and Marko V. Rodi{\'c} and Vladimir Divjakovi{\'c} and Velimir Popsavin},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={128},
  pages={
          13-24
        }
}
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13 Citations

13 Citations

Novel O-methyl goniofufurone and 7-epi-goniofufurone derivatives: synthesis, in vitro cytotoxicity and SAR analysis.
TLDR
Flow cytometry data confirmed that the cytotoxic effects of these analogues are mediated by apoptosis, additionally revealing that these molecules induced changes in the K562 cell cycle distribution.
Conformationally restricted goniofufurone mimics with halogen, azido or benzoyloxy groups at the C-7 position: Design, synthesis and antiproliferative activity
Design, synthesis, and biological evaluation of thiazole bioisosteres of goniofufurone through in vitro antiproliferative activity and in vivo toxicity
Semi-synthesis and anti-tumor activity of novel 25-OCH3-PPD derivatives incorporating aromatic moiety.
One-pot synthesis, anti-tumor evaluation and structure-activity relationships of novel 25-OCH3-PPD derivatives.
TLDR
In conclusion, the novel derivatives a5, a7, b5 and b7 could be further studied as potential candidates for the treatment of cancer and provides a theoretical reference for the exploration of new antiproliferative agents.
Chromatographic lipophilicity and pharmacokinetic behavior of some newly synthesized styryl lactone stereoisomers
TLDR
The RP-HPLC retention constants of several newly synthesized cytotoxic styryl lactone stereoisomers were determined as parameters of their lipophilicity and multiple linear regression analysis suggested that the volume of distribution depended on the lipopholicity and Ka (HSA-human serum albumin) and the absorption through membrane and permeability in the jejunum depend on thelipophilic and hydrogen bond donors.
A concise synthesis of (+)-goniofufurone, (+)-7-epi-goniofufurone, (+)-crassalactones B and C
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Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions.
Application of Suzuki-Miyaura Reaction in the Chemistry of Oxolan-2-ones
The reactions of 2-(2-chloroprop-2-en-1-yl)-5,5-dimethyloxolan-2-one with arylboronic acids in the presence of Pd(PPh3)4 and K2CO3 was used to synthesize novel oxolan-2-one…
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