Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.

@article{Francuz2017DesignSA,
  title={Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.},
  author={Jovana Francuz and Ivana Kova{\vc}evi{\'c} and Mirjana Popsavin and Goran Benedekovic and Bojana Sre{\'c}o Zelenovi{\'c} and Vesna Koji{\'c} and Dimitar S. Jakimov and Lidija D. Aleksi{\'c} and Gordana Bogdanovic and Tatjana Srdi{\'c}-Raji{\'c} and Eva S. Lon{\vc}ar and Marko V. Rodi{\'c} and Vladimir Divjakovi{\'c} and Velimir Popsavin},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={128},
  pages={
          13-24
        }
}
13 Citations
Novel O-methyl goniofufurone and 7-epi-goniofufurone derivatives: synthesis, in vitro cytotoxicity and SAR analysis.
TLDR
Flow cytometry data confirmed that the cytotoxic effects of these analogues are mediated by apoptosis, additionally revealing that these molecules induced changes in the K562 cell cycle distribution.
One-pot synthesis, anti-tumor evaluation and structure-activity relationships of novel 25-OCH3-PPD derivatives.
TLDR
In conclusion, the novel derivatives a5, a7, b5 and b7 could be further studied as potential candidates for the treatment of cancer and provides a theoretical reference for the exploration of new antiproliferative agents.
Chromatographic lipophilicity and pharmacokinetic behavior of some newly synthesized styryl lactone stereoisomers
TLDR
The RP-HPLC retention constants of several newly synthesized cytotoxic styryl lactone stereoisomers were determined as parameters of their lipophilicity and multiple linear regression analysis suggested that the volume of distribution depended on the lipopholicity and Ka (HSA-human serum albumin) and the absorption through membrane and permeability in the jejunum depend on thelipophilic and hydrogen bond donors.
Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions.
Application of Suzuki-Miyaura Reaction in the Chemistry of Oxolan-2-ones
The reactions of 2-(2-chloroprop-2-en-1-yl)-5,5-dimethyloxolan-2-one with arylboronic acids in the presence of Pd(PPh3)4 and K2CO3 was used to synthesize novel oxolan-2-one
...
...

References

SHOWING 1-10 OF 33 REFERENCES
Styryl lactones and their derivatives: biological activities, mechanisms of action and potential leads for drug design.
TLDR
The biological activities of styryl lactones focusing on cancer cells, the causal agent of Chagas' disease and the vectors for yellow fever and human lymphatic filariasis are discussed, as well as immunosuppressive and inflammatory processes.
Novel bioactive styryl-lactones: goniofufurone, goniopypyrone, and 8-acetylgoniotriol from Goniothalamus giganteus(annonaceae). X-Ray molecular structure of goniofufurone and of goniopypyrone
TLDR
Goniopypyrone was the most bioactive, showing nonselective ED50 values of ∼6.7 × 10–1µg/ml in each of the authors' three human tumour cell lines.
Two new styryl lactones, 9-deoxygoniopypyrone and 7-epi-goniofufurone, from Goniothalamus giganteus.
TLDR
Two new styryl lactones, 9-deoxygoniopypyrone and 7-epi-goniofufurone, were isolated from the stem bark of Goniothalamus giganteus and showed significant bioactivities to human tumor cells.
Comprehensive Reinvestigation of The Reaction of D-Aldoses With Meldrum'S Acid Yielding Mainly Chain Extended 3,6-Anhydro-2-Deoxy-Aldono-1,4-Lactones
ABSTRACT All diastereomeric aldo-D-pentoses and -D-hexoses were reacted with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) under basic conditions. A protocol was applied and optimized which was
...
...