Design, synthesis and evaluation of pyrazole derivatives as non-nucleoside hepatitis B virus inhibitors.

Abstract

In continuation of our efforts toward the discovery of potent non-nucleoside hepatitis B virus (HBV) inhibitors with novel structures, we have employed bioisosterism and hybrid pharmacophore-based strategy to explore the chemically diverse space of bioactive compounds. In this article, the original thiazole platform was replaced with pyrazole scaffold to… (More)
DOI: 10.1016/j.ejmech.2016.07.048

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