Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.

@article{Cheng2008DesignSA,
  title={Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.},
  author={Xian-Chao Cheng and Qiang Wang and Hao Fang and Wei Tang and Wen-fang Xu},
  journal={Bioorganic & medicinal chemistry},
  year={2008},
  volume={16 10},
  pages={5398-404}
}
A series of novel sulfonyl pyrrolidine derivatives were designed, synthesized and assayed for their inhibitory activities on matrix metalloproteinase 2 (MMP-2) and aminopeptidase N (AP-N). The results showed that these pyrrolidine derivatives exhibited highly selective inhibition against MMP-2 as compared with AP-N. Compounds 6a-d were more potent MMP-2 inhibitors than the positive control LY52. The structure-activity relationships were also briefly discussed. 

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