Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.

@article{Li2014DesignSA,
  title={Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.},
  author={Su-Yi Li and Neng Jiang and Sai-Sai Xie and Kelvin D.G. Wang and Xiaobing Wang and Lingyi Kong},
  journal={Organic \& biomolecular chemistry},
  year={2014},
  volume={12 5},
  pages={
          801-14
        }
}
A series of tacrine-rhein hybrid compounds have been designed and synthesized as novel multifunctional potent ChE inhibitors. Most of the compounds inhibited ChEs in the nanomolar range in vitro effectively. Compound 10b was one of the most potent inhibitors and was 5-fold more active than tacrine toward AChE, and it also showed a moderate BuChE inhibition with an IC50 value of 200 nM. Kinetic and molecular modeling studies of 10b also indicated that it was a mixed-type inhibitor binding… 
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