Design, synthesis and evaluation of a novel class of glucosamine mimetic peptides containing 1,3-dioxane.

@article{Zeng2015DesignSA,
  title={Design, synthesis and evaluation of a novel class of glucosamine mimetic peptides containing 1,3-dioxane.},
  author={Li Zeng and Guichao Xu and Pengchao Gao and Meng Zhang and Hong Li and Jianwei Zhang},
  journal={European journal of medicinal chemistry},
  year={2015},
  volume={93},
  pages={109-20}
}
A number of novel 2-(N-(2-(5,5-dimethyl-1,3-dioxane-2-yl)ethyl)aminoacyl)amino-2-deoxy- d-glucopyranoside were synthesized from a readily available starting material, glucosamine, 2,2-dimethyl-1,3-propanediol and 1,1,3,3-tetramethoxypropane, and evaluated for their anti-inflammatory activity. Our results showed that all of the compounds tested exhibited a significant inhibition of xylene-induced inflammation in mice.