Design, synthesis and cytotoxic evaluation of quinazoline-2,4,6-triamine and 2,6-diaminoquinazolin-4(3H)-one derivatives

  title={Design, synthesis and cytotoxic evaluation of quinazoline-2,4,6-triamine and 2,6-diaminoquinazolin-4(3H)-one derivatives},
  author={Audif{\'a}s-Salvador Matus-Meza and Marco Antonio Velasco-Vel{\'a}zquez and Francisco Hern{\'a}ndez-Luis},
  journal={Medicinal Chemistry Research},
A series of quinazoline-2,4,6-triamine (quinazoline) and 2,6-diaminoquinazolin-4(3H)-one (quinazolinone) derivatives were designed, synthesized and evaluated as cytotoxic agents in three cancer cell lines (HCT-15, SKOV-3, and MDA-MB-231) using conventional MTT assay. Of the tested compounds, only eleven quinazoline derivatives showed activity against all the tested cell lines, at 24 h of exposure. Among them, the compounds 3e and 3f exhibited the highest cytotoxic activity, with the most… Expand
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