Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis.

@article{Upadhayaya2009DesignSA,
  title={Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis.},
  author={Ram Shankar Upadhayaya and Girish Kulkarni and Nageswara Rao Vasireddy and Jaya Kishore Vandavasi and Shailesh Satish Dixit and Vivek Sharma and Jyoti Chattopadhyaya},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 13},
  pages={4681-92}
}
A new series of 20 quinoline derivatives possessing triazolo, ureido and thioureido substituents have been synthesized and their antimycobacterial properties have been evaluated. Compounds 10, 22 and 24 inhibited Mycobacterium tuberculosis H37Rv up to 96%, 98% and 94% respectively, at a fixed concentration of 6.25 microg/mL. Minimum inhibitory concentration of 3.125 microg/mL was obtained for compound 10 and 24, while for compound 22 it was 6.25 microg/mL. Molecular docking calculations suggest… CONTINUE READING

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