Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents.

Abstract

A novel series of 6-chloro-2-p-tolylquinazolinone and substituted-(4-methylbenzamido)benzamide (1-20) were designed, synthesized and evaluated for their in-vitro antitumor activity. Compounds 3, 14 and 16 possessed remarkable broad-spectrum antitumor activity. Compound 16 was found to be a particularly active growth inhibitor of the renal cancer (GI50 = 4… (More)
DOI: 10.1016/j.ejmech.2014.04.029

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