Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.

Abstract

A naturally occurring homoisoflavonoid, cremastranone (1) inhibited angiogenesis in vitro and in vivo. We developed an analogue SH-11037 (2) which is more potent than cremastranone in human retinal microvascular endothelial cells (HRECs) and blocks neovascularization in animal models. Despite their efficacy, the mechanism of these compounds is not yet fully… (More)
DOI: 10.1016/j.bmcl.2016.07.043

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Cite this paper

@article{Lee2016DesignSA, title={Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.}, author={Bit Na Lee and Wei Sun and Hyungjun Lee and Halesha Basavarajappa and Rania S. Sulaiman and Kamakshi L Sishtla and Xiang Fei and Timothy W Corson and Seung-Yong Seo}, journal={Bioorganic & medicinal chemistry letters}, year={2016}, volume={26 17}, pages={4277-81} }