Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors.


Herein we have reported design, synthesis and in vitro biological evaluation of a library of bicyclic lactams that led to the discovery of compounds 6 and 7 as a novel class of α-glucosidase inhibitors. They inhibited α-glucosidase (yeast origin) in a mixed type of inhibition with an IC50 of ∼150 nM. Molecular docking studies further substantiated screening… (More)
DOI: 10.1016/j.ejmech.2015.04.059


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