Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase.

@article{Menndez2017DesignSA,
  title={Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase.},
  author={Cintia Men{\'e}ndez and Brunella Biscussi and Sebasti{\'a}n Accordino and A Paula Murray and Dar{\'i}o C. Gerbino and Gustavo Appignanesi},
  journal={Bioorganic chemistry},
  year={2017},
  volume={75},
  pages={201-209}
}
The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold. In order to understand and rationalize the mode of action of these target structures a theoretical study was initially conducted. From the results of rational design, a new variety of amphiphilic xanthone derivatives were synthesized, structurally characterized and evaluated as potential anti-Alzheimer agents. The results showed that most of… CONTINUE READING
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