Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors.

@article{Loudni2007DesignSA,
  title={Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors.},
  author={Lynda Loudni and Jo{\"e}lle Roche and Vincent Potiron and Jonathan A. Clarhaut and Christian Bachmann and Jean-Pierre Gesson and Isabelle Tranoy-Opalinski},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 17},
  pages={4819-23}
}
New histone deacetylase inhibitors have been synthesized and evaluated for their activity against non-small lung cancer cell line H661. These compounds have been designed with diversely substituted 1,4-benzodiazepine-2,5-dione moieties as cyclic peptide mimic cap structures, and a hydroxamate side chain. Biological evaluations demonstrated that benzodiazepine-based HDACi bearing an aromatic substituent at the N1 position exhibited promising antiproliferative and HDAC-inhibitory activities. 

Citations

Publications citing this paper.
Showing 1-3 of 3 extracted citations

Similar Papers

Loading similar papers…