Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.

@article{Wang2012DesignSA,
  title={Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.},
  author={Tiansheng Wang and Leonard Duncan and Wenxin Gu and Hardwin O'Dowd and Yunyi Wei and Emanuele Perola and Jonathan Parsons and Christian H Gross and Cameron Stuver Moody and S. J. Ryan Arends and Paul S. Charifson},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 11},
  pages={3699-703}
}
A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD(+)-dependent DNA ligase that possess potency against Gram-positive bacteria.