Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease.

Abstract

A series of compounds containing an α,β-unsaturated carbonyl moiety, such as chalcones and coumarins were designed, synthesized and tested in a variety of assays to assess their potential as anti-Alzheimer's disease (AD) agents. The investigations included the inhibition of cholinesterases (AChE, BuChE), the inhibition of amyloid beta (Aβ) self-assembly and… (More)
DOI: 10.1016/j.bmcl.2013.02.103

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@article{Bag2013DesignSA, title={Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease.}, author={Seema Bag and Sanjukta Ghosh and Rekha Tulsan and Abha Sood and Weihong Zhou and Christine Schifone and Michelle T. Foster and Harry Levine and B{\'e}la T{\"o}r{\"o}k and Marianna T{\"o}r{\"o}k}, journal={Bioorganic & medicinal chemistry letters}, year={2013}, volume={23 9}, pages={2614-8} }