Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1H)-quinolones

  title={Design, synthesis and antimycobacterial activities of
  author={Abraham Abebe Wube and Antje Huefner and Christina Thomaschitz and Martina Blunder and Manfred Kollroser and Rudolf Bauer and Franz Bucar},
  booktitle={Bioorganic & medicinal chemistry},
A series of 23 new 1-methyl-2-alkenyl-4(1H)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as Mycobacterium fortuitum, M. smegmatis and M. phlei. The compounds displayed good to excellent inhibition of the growth of the mycobacterial test strains with improved antimycobacterial activity compared to the hit compound, evocarpine. The most active compounds, which possessed chain length of 11-13… CONTINUE READING
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