Design, synthesis and DNA interactions of a chimera between a platinum complex and an IHF mimicking peptide.

Abstract

Conjugation of metal complexes with peptide scaffolds possessing high DNA binding affinity has shown to modulate their biological activities and to enhance their interaction with DNA. In this work, a platinum complex/peptide chimera was synthesized based on a model of the Integration Host Factor (IHF), an architectural protein possessing sequence specific… (More)
DOI: 10.1039/c5ob01885d

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