Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors.

@article{Zheng2013DesignSQ,
  title={Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors.},
  author={Youguang Zheng and M. Zheng and X. Ling and Y. Liu and Yunsheng Xue and Lin An and N. Gu and M. Ji},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2013},
  volume={23 12},
  pages={
          3523-30
        }
}
Novel pyrazole-benzimidazole derivatives have been designed and synthesized. The entire target compounds were determined against cancer cell lines U937, K562, A549, LoVo and HT29 and were screened for Aurora A/B kinase inhibitory activity in vitro. The compounds 7a, 7b, 7i, 7k and 7l demonstrated significant cancer cell lines and Aurora A/B kinase inhibitory activities. Molecular modeling studies suggested the derivatives have bound in the active site of Aurora A kinase through the formation of… Expand
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