Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors.

@article{Ma2004DesignSP,
  title={Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors.},
  author={Yongmin Ma and Wei Luo and Peter J. Quinn and Zudong Liu and Robert C. Hider},
  journal={Journal of medicinal chemistry},
  year={2004},
  volume={47 25},
  pages={6349-62}
}
The synthesis of a range of novel 3-hydroxypyridin-4-ones and 3-hydroxypyran-4-ones linked with different coumarin substituents is described. These compounds have been developed in order to provide a series of molecular probes for the quantification of intracellular labile iron pools. An evaluation of the effect of iron(III) on fluorescence intensity was undertaken. Chelation of iron(III) causes quenching of fluorescence. The relationship between iron(III) concentration and the extent of… CONTINUE READING