Design, synthesis, pharmacological evaluation and descriptor based similarities study of N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1-yl]acetamides as potential antipsychotics.

Abstract

A series of novel N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1-yl]acetamides was designed, synthesized and evaluated for anti-dopaminergic activity, anti-serotonergic activity and catalepsy induction studies in mice as an approach to novel potential antipsychotic agent. Antipsychotic activity of these compounds in terms of blocking of dopaminergic… (More)

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Cite this paper

@article{Dash2012DesignSP, title={Design, synthesis, pharmacological evaluation and descriptor based similarities study of N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1-yl]acetamides as potential antipsychotics.}, author={Radha Charan Dash and Sharad H. Bhosale and Suhas M. Shelke and Mugdha R. Suryawanshi and Kakasaheb Ramoo Mahadik}, journal={Medicinal chemistry (Shariqah (United Arab Emirates))}, year={2012}, volume={8 6}, pages={1069-75} }