Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase.

Abstract

Beta-secretase is the key enzyme involved in Alzheimer's disease thus; inhibition of the enzyme can lead to a potential anti-Alzheimer drug. In the search of an effective lead candidate, we have designed non-peptide inhibitor molecules based on amino aromatic heterocyclic motifs specifically, substituted 1,2,4-thiadiazole analogues. In silico modelling was… (More)
DOI: 10.1016/j.bioorg.2014.09.002

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Cite this paper

@article{Gurjar2014DesignSI, title={Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase.}, author={Archana S Gurjar and Vincenza Andrisano and Angela De Simone and Vinay S. Velingkar}, journal={Bioorganic chemistry}, year={2014}, volume={57}, pages={90-8} }