Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles.

@article{Kumar2012DesignSC,
  title={Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles.},
  author={Ajay Kumar and Poonam Lohan and Deepak Kumar Aneja and Girish Kumar Gupta and Dhirender Kaushik and Om Prakash},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={50},
  pages={81-9}
}
Two series of compounds namely, 4-aryl/heteroaryl hydrazino-3-acetyl-6-methyl-2H-pyran-2-ones (4a-4j) and pyrano[4,3-c]pyrazoles (6a-6e and 6g) were synthesized starting from 3-acetyl-4-chloro-6-methyl-2H-pyran-2-one (2). Estimation of pharmacotherapeutic potential, possible molecular mechanism of action, toxic/side effects and interaction with drug-metabolizing enzymes were made for the synthesized compounds on the basis of prediction of activity spectra for substances (PASS) prediction… CONTINUE READING