Design, synthesis, bioconversion, and pharmacokinetics evaluation of new ester prodrugs of olmesartan.

Abstract

Synthesis of new ester prodrugs of olmesartan is described. Their in vitro stabilities in simulated gastric juice, rat plasma, and rat liver microsomes were tested. And the pharmacokinetic parameters for olmesartan after their oral administration were also estimated and compared with those in case of olmesartan medoxomil. Compounds 13 and 14 demonstrated… (More)
DOI: 10.1016/j.ejmech.2011.05.019

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Cite this paper

@article{Chang2011DesignSB, title={Design, synthesis, bioconversion, and pharmacokinetics evaluation of new ester prodrugs of olmesartan.}, author={Jeong-Soo Chang and Mohammed I El-Gamal and Woong San Lee and Hanan S Anbar and Hye Jin Chung and Hyun-il Kim and Young-jin Cho and Bong Sang Lee and Sun Ahe Lee and Ji Yun Moon and Dong Jin Lee and Hong-Ryeol Jeon and J. S. L. Lee and Young Wook Choi and Chang-Hyun Oh}, journal={European journal of medicinal chemistry}, year={2011}, volume={46 9}, pages={3564-9} }