Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.

@article{Ran2009DesignSA,
  title={Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.},
  author={Chongzhao Ran and Xiaoyin Xu and Scott B. Raymond and Brian J Ferrara and Krista L. Neal and Brian J. Bacskai and Zdravka O Medarova and Anna Moore},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 42},
  pages={15257-61}
}
Amyloid-beta (Abeta) deposits have been identified as key players in the progression of Alzheimer's disease (AD). Recent evidence indicates that the deposits probably precede and induce the neuronal atrophy. Therefore, methods that enable monitoring the pathology before clinical symptoms are observed would be beneficial for early AD detection. Here, we report the design, synthesis, and testing of a curcumin-derivatized near-infrared (NIR) probe, CRANAD-2. Upon interacting with Abeta aggregates… CONTINUE READING