Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.

@article{Jiang2006DesignSA,
  title={Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.},
  author={Tao Jiang and Kelli L. Kuhen and Karen C Wolff and Hong Yin and Kimberly Bieza and Jeremy Caldwell and Badry D. Bursulaya and Tove Tuntland and Kanyin E Zhang and Donald S Karanewsky and Yun He},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 8},
  pages={2109-12}
}
A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics. 

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