Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens.

@article{Odagiri2013DesignSA,
  title={Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens.},
  author={Takashi Odagiri and Hiroaki Inagaki and Yuichi Sugimoto and Masatoshi Nagamochi and Rie N Miyauchi and Junichi Kuroyanagi and Takahiro Kitamura and Satoshi Komoriya and Hisashi Takahashi},
  journal={Journal of medicinal chemistry},
  year={2013},
  volume={56 5},
  pages={1974-83}
}
Novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]- 8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 2a and 2b were designed and synthesized to obtain potent antibacterial drugs for the treatment of respiratory tract infections. Among these, compound 2a possessing (S)-configuration for the asymmetrical carbon on the pyrolidine moiety at the C-7 position of the quinolone scaffold exhibited potent in vitro antibacterial activity against… CONTINUE READING
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