Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents.

Abstract

To identify novel multi-target-directed drug candidates for the treatment of cancer, a series of benzoselenazole-stilbene hybrids were synthesised by combining the pharmacophores of resveratrol and ebselen. The biological assay indicated that all of the hybrids exhibited antiproliferative activities against four human cancer cell lines and demonstrated good… (More)
DOI: 10.1016/j.ejmech.2015.03.030

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Cite this paper

@article{Yan2015DesignSA, title={Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents.}, author={Jun Yan and Yueyan Guo and Yali Wang and Fei Mao and Ling Huang and Xingshu Li}, journal={European journal of medicinal chemistry}, year={2015}, volume={95}, pages={220-9} }