Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors.

@article{Zarghi2010DesignSA,
  title={Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors.},
  author={Afshin Zarghi and Razieh Ghodsi},
  journal={Bioorganic & medicinal chemistry},
  year={2010},
  volume={18 16},
  pages={5855-60}
}
A new series of ketoprofen analogs were synthesized to evaluate their biological activities as selective cyclooxygenase-2 (COX-2) inhibitors. In vitro COX-1 and COX-2 inhibition studies showed that all compounds were potent and selective inhibitors of the COX-2 isozyme with IC(50) values in the highly potent 0.057-0.085 microM range, and COX-2 selectivity… CONTINUE READING