Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents.

@article{Reddy2008DesignSA,
  title={Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents.},
  author={M. Venkat Ramana Reddy and Muralidhar Reddy Mallireddigari and Stephen C. Cosenza and Venkat R. Pallela and N. Mohamud Iqbal and Kimberly A Robell and Anthony D. Kang and E. P. Reddy},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 1},
  pages={
          86-100
        }
}
Cell cycle progression is regulated by cyclins and cyclin-dependent kinases, which are formed at specific stages of the cell cycle and regulate the G1/S and G2/M phase transitions, employing a series of "checkpoints" governed by phosphorylation of their substrates. Tumor development is associated with the loss of these checkpoint controls, and this provides an approach for the development of therapeutic agents that can specifically target tumor cells. Here, we describe the synthesis and SAR of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Similar Papers

Loading similar papers…