Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer

@article{Xie2017DesignSA,
  title={Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential I$\kappa$B kinase $\beta$ inhibitors for the treatment of pancreatic cancer},
  author={Xuemeng Xie and Jinfu Tu and Heyi You and Bingren Hu},
  journal={Drug Design, Development and Therapy},
  year={2017},
  volume={11},
  pages={1439 - 1451}
}
Given the important role that inhibitory kappa B (IκB) kinase β (IKKβ) plays in pancreatic cancer (PC) development and progression, inhibitors targeting IKKβ are believed to be increasingly popular as novel anti-PC therapies. Two synthetic molecules, named EF24 and EF31, exhibited favorable potential in terms of inhibition of both IKKβ activity and PC cell proliferation. Aiming to enhance their cellular efficacy and to analyze their structure–activity relationship, four series of EF24 and EF31… Expand
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