Design, synthesis, and biological activity evaluation of campthothecin‐HAA‐Norcantharidin conjugates as antitumor agents in vitro

@article{Wang2018DesignSA,
  title={Design, synthesis, and biological activity evaluation of campthothecin‐HAA‐Norcantharidin conjugates as antitumor agents in vitro},
  author={Xian H Wang and Mei-Hui Huang and Changkuo Zhao and Chan Li and Lang Xu},
  journal={Chemical Biology \& Drug Design},
  year={2018},
  volume={93},
  pages={986 - 992}
}
Three components of Camptothecin, hydroxyacetic acid, and functionalized norcantharidins were constructed together to form a novel series of camptothecin derivatives in a good yield. The synthesized campthothecin‐HAA‐norcantharidin conjugate pro‐drugs could suppress cancer cell growth in vitro. These conjugated pro‐drug molecules possess therapeutic potential as novel bi‐functional conjugates platforms for cancer treatment. 

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