Design, synthesis, and antipicornavirus activity of 1-[5-(4-arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one derivatives.

@article{Chang2005DesignSA,
  title={Design, synthesis, and antipicornavirus activity of 1-[5-(4-arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one derivatives.},
  author={Chih-Shiang Chang and Ying-Ting Lin and Shin-Ru Shih and C Lee and Y Lee and Chia-Liang Tai and Sung-Nien Tseng and Jyh-Haur Chern},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 10},
  pages={3522-35}
}
A series of pyridylimidazolidinone derivatives was synthesized and tested in vitro against enterovirus 71 (EV71). On the basis of compound 33 (DBPR103), introduction of a methyl group at the 2- or 3-position of the linker between the imidazolidinone and the biphenyl resulted in markedly improved antiviral activity toward EV71 with IC(50) values of 5.0 nM (24b) and 9.3 nM (14a), respectively. Increasing the branched chain to propyl resulted in a progressive decrease in activity, while inserting… CONTINUE READING