Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives.

@article{Rezaei2009DesignSA,
  title={Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives.},
  author={Zahra Poor Rezaei and Soghra Khabnadideh and Keyvan Pakshir and Zahra Hossaini and Fatemeh Amiri and Elham Assadpour},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 7},
  pages={
          3064-7
        }
}
This study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (14DM). The chemical structures of the new compounds were confirmed by elemental and spectral ((1)H NMR, (13)C NMR, Mass) analyses. Compounds were designed by a generating virtual library of compounds and docking them into the enzyme active site. Furthermore, they were found to have in vitro activity against Microsporum… CONTINUE READING
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