Design, structural, and immuno-analytical properties of antigenic bioconjugates comprising a beta-amyloid-plaque specific epitope.

@article{Manea2008DesignSA,
  title={Design, structural, and immuno-analytical properties of antigenic bioconjugates comprising a beta-amyloid-plaque specific epitope.},
  author={Marilena Manea and Michael Przybylski and Ferenc Hudecz and G{\'a}bor Mez{\"o}},
  journal={Biopolymers},
  year={2008},
  volume={90 2},
  pages={
          94-104
        }
}
Immunotherapeutic approaches are investigated for treatment of neurodegenerative diseases of the Alzheimer's dementia (AD) type. The identification of a beta-amyloid-plaque specific epitope, Abeta(4-10) (4FRHDSGY10), recognized by therapeutically active antibodies from transgenic AD mice could provide the basis for the development of AD vaccines. Here we report on the synthesis, structural and immuno-analytical characterization of bioconjugates comprising the beta-amyloid(4-10) epitope as new… CONTINUE READING