Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes.

@article{Deane2001DesignPA,
  title={Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes.},
  author={Janet E Deane and Eleanor Y M Sum and Joel P. Mackay and Geoffrey J Lindeman and Jane E. Visvader and Jacqueline Mary Matthews},
  journal={Protein engineering},
  year={2001},
  volume={14 7},
  pages={493-9}
}
The nuclear LIM-only (LMO) transcription factors LMO2 and LMO4 play important roles in both normal and leukemic T-cell development. LIM domains are cysteine/histidine-rich domains that contain two structural zinc ions and that function as protein-protein adaptors; members of the LMO family each contain two closely spaced LIM domains. These LMO proteins all bind with high affinity to the nuclear protein LIM domain binding protein 1 (ldb1). The LMO-ldb1 interaction is mediated through the N… CONTINUE READING