Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides.

@article{Musilek2011DesignEA,
  title={Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides.},
  author={Kamil Musilek and Martin Dole{\vz}al and Frank J. Gunn-Moore and Kamil Ku{\vc}a},
  journal={Medicinal research reviews},
  year={2011},
  volume={31 4},
  pages={
          548-75
        }
}
Organophosphate pesticides (OPPs; e.g. chlorpyrifos, diazinon, paraoxon) are a wide and heterogeneous group of organophosphorus compounds. Their biological activity of inhibiting acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) ranks them as life endangering agents. The necessary treatment after OPP exposure involves the use of parasympatolytics (e.g. atropine), oxime reactivators (e.g. obidoxime), and anticonvulsive drugs (e.g. diazepam). Therefore, the reactivators of AChE are… CONTINUE READING

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