Design, construction, and characterization of a large synthetic human antibody phage display library.

@article{Silacci2005DesignCA,
  title={Design, construction, and characterization of a large synthetic human antibody phage display library.},
  author={Michael W. Silacci and Simon Brack and Giulia Schirru and Jessica M{\aa}rlind and Anna Ettorre and Adrian Merlo and Francesca Viti and Dario Neri},
  journal={Proteomics},
  year={2005},
  volume={5 9},
  pages={
          2340-50
        }
}
Advances in proteomic research allow the identification of several hundred protein components in complex biological specimens. Structural information is typically lost during proteomic investigations. For this reason, the rapid isolation of monoclonal antibodies specific to proteins of interest would allow the study of structurally intact biological specimens, thus providing complementary proteomic information. Here, we describe the design, construction, characterization, and use of a large… CONTINUE READING
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