Design, Synthesis and Microbiological Evaluation of Ampicillin Tetramic acid Hybrid Antibiotics

@inproceedings{Cherian2016DesignSA,
  title={Design, Synthesis and Microbiological Evaluation of Ampicillin Tetramic acid Hybrid Antibiotics},
  author={Philip T. Cherian and Aditi Deshpande and Martin N. Cheramie and David F. Bruhn and Julian Gregston Hurdle and Richard E. Lee},
  booktitle={The Journal of Antibiotics},
  year={2016}
}
Exploiting iron-uptake pathways by conjugating β-lactam antibiotics with iron-chelators, such as catechol and hydroxamic acid is a proven strategy to overcome permeability-related resistance in Gram-negative bacteria. As naturally occurring iron-chelating tetramic acids have not been previously examined for this purpose, an exploratory series of novel ampicillin–tetramic acid hybrids that structurally resemble ureidopenicillins was designed and synthesized. The new analogs were evaluated for… CONTINUE READING