Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors.

Abstract

SecA, a key component of the bacterial Sec-dependent secretion pathway, is an attractive target for the development of new antimicrobial agents. Through a combination of virtual screening and experimental exploration of the surrounding chemical space, we identified a hit bistriazole SecA inhibitor, SCA-21, and studied a series of analogues by systematic… (More)
DOI: 10.1002/cmdc.201500447

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